MUSCLE3X
INFLAMMATION
INFLAMMATION
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Overview
Inflammation can have both positive and negative health effects. Acute inflammation works with the immune system to address infectious and non-infectious cellular damage. (1) However, when inflammation becomes chronic, it can seriously impact health. For example, studies have shown a correlation between chronic inflammation and all-cause, cancer, cardiovascular, and cerebrovascular mortality. (10)(12)
Curcumin
Curcumin (Curcuma longa)
600–1,000 mg, total per day, minimum 8–10 weeks (4)(13)
- Curcumin decreased C-reactive protein (CRP) (-0.58 mg/l), tumor necrosis factor-alpha (TNF-α) (-3.48 pg/ml), interleukin 6 (IL-6) (-1.31 pg/ml), and malondialdehyde (MDA) (-0.33 umol/l), and increased superoxide dismutase (SOD) activity (20.51 u/l) and total antioxidant capacity (TAC) (0.21 mmol/l). (3)
- In patients with various chronic diseases, curcumin decreased CRP (-3.67 mg/l) and hs-CRP concentrations. (4)
- Compared to placebo, curcumin decreased IL-6 by ~49%, TNF-α by ~63%, and MDA by ~38% in patients with diabetes mellitus. (13)
Omega-3 fatty acids (EPA/DHA)
Omega-3 fatty acids (EPA/DHA)
2.5 g, total per day, minimum 12 weeks (7)(15)
- In patients with various health conditions, omega-3s moderately decreased serum CRP, as well as IL-6 and TNF-α with a smaller effect. (5)
- Compared to placebo, omega-3 supplementation decreased total serum cortisol by 19% and IL-6 levels by 33% during a stressful event, and CRP by ~30%, IL-6 by ~22%, and TNF-α by ~16% in patients with chronic kidney disease undergoing hemodialysis. (7)(15)
Probiotics
Probiotics
1.6 × 109 CFU, total per day, minimum 8 weeks (8)(11)
- Prebiotics and probiotics modulate the intestinal microbiome and decrease oxidative stress and inflammation by increasing intestinal anaerobes and maintaining the integrity of the intestinal barrier. (6)
- Compared to placebo, a multistrain synbiotic reduced TNF-α by ~6% and hs-CRP by ~10% in postmenopausal females with obesity and a history of hormone-receptor-positive breast cancer. (11)
- Compared to placebo, Lactobacillus rhamnosus GG reduced IL1-Beta and lipopolysaccharide concentrations by ~ 35% and ~30%, respectively, in patients with CAD. (8)
Quercetin
Quercetin
≥ 500 mg, total per day, minimum of 8 weeks (2)(9)(14)
- In individuals with chronic diseases, quercetin had a large effect on decreasing IL-6 and a smaller effect on decreasing serum CRP. (9)
- Quercetin decreased TNF-α and IL-6 in females with polycystic ovarian syndrome. (14)
- Compared to placebo, quercetin increased serum TAC by ~20% in post-myocardial infarction patients. (2)
Materials
Materials
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Dimensions
Care Instructions
Care Instructions
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